![]() Definitions Dr.T.V.Rao MDĮpidemiology Primary drug resistance initial drug resistance Secondary drug resistance acquire drug resistance Treatment of tuberculosis: guidelines for national programmes, 3rd ed. ![]() Multidrug-resistant tuberculosis (MDRTB) Resistance to Isoniazid and Rifampicin Extensively (extremely) drug-resistant (XDR-TB) MDR-TB plus resistance to a second line injectable drug such as Amikacin plus a quinolone. ![]() Why INH and Rifampin are important Dr.T.V.Rao MD Most potent and bactericidal Tb can be treated effectively with INH+Rif alone Mono-resistance to one of them can be treated effectively with a regimen containing the other agent with very low failure rate (2.5-5%) Failure rate when INH+Rif resistant is 44% in non-HIV and 70% in HIV patients Duration required for cure doubles to triples. Drug resistant tuberculosisMDR-TB, XMDR-TB Dr.T.V.Rao MD Dr.T.V.Rao MD
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